Gastrohepatology
Gastrohepatology testing
The Liver Molecular Genetics laboratories at King’s College Hospital form part of the SE GLH, providing specialist genetic testing services for a range of gastric and hepatic diseases.
The laboratory was founded with close collaboration between clinical, laboratory and academic groups with the aim to change clinical practice worldwide.
As early adopters of Next Generation Sequencing technology, the laboratory has considerable experience in the specialist interpretation of results and staff members actively contribute to patient management through multi-disciplinary meetings.
The laboratory was the first to clone the human bile salt export pump protein (BSEP) – a major transporter in the liver, and are currently taking part in a worldwide collaborative study investigating further genetic abnormalities in children with the aim of improving the clinical treatment of patients. The laboratory has an active research and development programme with close affiliation to King’s College London (KCL).
Tests offered and turnaround times
The Gastrohepatology genetic testing repertoire is provided jointly by the Liver Molecular Genetics Laboratory and Synnovis Analytics Molecular Pathology Laboratory, both based at King’s College Hospital. Please ensure the correct request form is used for the test(s) being requested so that referrals are directed to the appropriate laboratory:
Liver Molecular Genetics Laboratory:
- R171 – Cholestasis (84 days)
- R172 – Wilson disease (42 days)
- R173 – Polycystic liver disease (42 days)
- R175 – Pancreatitis (42 days)
- R177 – Hirschsprung disease – familial (42 days)
- R331 – Intestinal failure (84 days)
Synnovis Analytics Molecular Pathology Laboratory:
- R168 – Non-acute porphyrias (42 days)
- R169 – Acute intermittent porphyria (42 days)
- R170 – Variegate porphyria (42 days)
- R176 – Gilbert syndrome (14 days)
Sample type and requirements
- Specimen will not be accepted unless correctly labelled, packed and accompanied by a fully completed request form
- All packaging should conform to PI 650 standards
Acceptance criteria
Samples may be rejected for the following reasons:
- Samples and request form do not show at least three identical patient identifiers
- The sample is in the incorrect collection media
- The request form is not sufficiently completed
- The sample is not of sufficient volume
- The sample is too old
It is the responsibility of the person collecting the sample to ensure it is correctly labelled.
For scientific and clinical advice
If you wish to discuss the results or have any scientific queries please contact the laboratory on +44(0)20 3299 4625 between the hours of 09:00 and 17:30 Mon – Fri, or email kch-tr.kchlmgadmin@nhs.net.
For clinical advice please contact Prof. Richard Thompson on +44(0)20 3299 4296 between the hours of 09:00 and 17:30 Mon – Fri, or email kch-tr.kchlmgadmin@nhs.net.
Policy on protection of personal information
For complaints
SE GLH: Record of Discussion form
The Record of Discussion form can be downloaded and used to guide and record the patient’s consent. This should be saved in local patient records and does not need to be sent with the request form.
Lab address and opening hours
09:00 – 17:30 Mon-Fri
LIVER MOLECULAR GENETICS (LMG) SERVICE
Liver Labs, Institute of Liver Studies,
3rd Floor Cheyne Wing,
King’s College Hospital NHS Foundation Trust,
Denmark Hill,
London,
SE5 9RS
+44 (0)20 3299 2253/4625
SYNNOVIS ANALYTICS MOLECULAR PATHOLOGY LABORATORY
Molecular Pathology c/o Central Specimen Reception,
Blood Sciences Laboratory,
Ground Floor Bessemer Wing,
King’s College Hospital,
Denmark Hill,
London,
SE5 9RS
+44 (0)20 3299 2265/1246
Key contacts
Liver Molecular Genetics
Clinical Lead – Prof Richard Thompson
Laboratory Lead – Sammi Allouni
Synnovis Molecular Pathology
Clinical Lead – Prof David Rees
Laboratory Lead – Frances Smith
