Cancerous cells and tumours leak DNA into the bloodstream as the tumour grows. It is possible to look for these fragments of DNA as a way to determine if a tumour is present and so confirm a diagnosis.

This project aims to provide evidence, including the health economics, for the expansion of ctDNA testing in the NHS to support early diagnosis of cancer, diagnosis of cancer for patients who currently cannot have a tumour biopsy, or do not yet have a confirmed diagnosis​.

This form of testing could lead to much earlier diagnosis of cancer leading to faster and more effective treatment. This could save the lives of patients living with cancer.

What are we doing?

Starting with non-small cell lung cancer patients as an exemplar, we will provide evidence for the expansion of ctDNA testing to support early diagnosis of cancer and diagnosis of cancer for patients who currently cannot have a tumour biopsy or do not yet have a confirmed diagnosis.

Samples are being taken from patients with non-small cell lung cancer. A sample of blood can be used to look for and measure the amount of ctDNA and identify specific mutations (changes) in the DNA.

Why is this important?

The NHS has a clear ambition to prevent cancer wherever possible.

If we can identify people who have lung cancer without the need for surgery, this will greatly benefit patients.