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Cancer Whole Genome Sequence

How to order a Cancer Whole Genome Sequence Test

  1. Identify which Cancer WGS test you need. Is it definitely a Whole Genome Sequencing test?

    Use our Find a Test Directory to search by condition, gene or R number and it will tell you what type of test method or technology you require.

    Order or find a test

  2. Check if your patient is eligible

    Use our Find a Test Directory to search by condition, gene or R number and it will tell you what the eligibility criteria is for each test. You will need to explicitly explain how your patient meets the eligibility criteria.

    Genetic testing may occasionally be appropriate outside these criteria following discussion at a specialist MDT with a geneticist present.

    Order to find a test

  3. Fill in the Whole Genome Sequencing Test Order Form

    Cancer WGS Order Form for tumour and parallel germline testing

    For help to complete the form, GeNotes has some useful information. You’ll need to complete the form electronically as we don’t accept handwritten forms. One Test Order Form per trio.

    You must include on the form how your patient meets the eligibility criteria.

    Include the patient’s ethnicity to improve accuracy of results. We need to compare results with population specific data to understand if variant could be causative

    Don’t forget to include your HPO terms on the order form which start with the terms HP. Even those that might not seem relevant, otherwise we might miss relevant findings. Find them here 

    Send the completed forms to gstt.wgs@nhs.net

  4. Ensure your patient has consented to the test

    Record of discussion form & clinician guides

    Get help to complete a Record of Discussion Form here

    Send the completed forms to gstt.wgs@nhs.net

  5. We require two samples : one somatic sample from the tumour as fresh frozen tissue and a germline blood sample in an EDTA tube.

    DNA will be damaged if it’s not stored in the correct format.

    Have you organised a blood sample? If the patient is organising a local blood test, they will need a specific blood form. Please complete all the patient details and demographics before giving the form to a patient.

    Blood form

  6. Send all referrals to Gst-tr.wgs@nhs.net

    Look out for an email from the WGS team.

    We’ll email you if there is a problem. Testing will be cancelled after 16 weeks if the referral isn’t complete

Here’s a reminder of the forms that you need for Cancer WGS testing

Record of discussion form Test order form for Cancer WGS Blood form if your patient is having a local blood test Patient information sheets A guide for completing the WGS TOF

We have established WGS referral pathways within distinct specialities at many NHS Trusts.  If you don’t know how to make a referral within your Trust please contact us on Gst-tr.hellogenomics@nhs.net

Extra support

Watch this video for a step by step guide to completing the WGS test order form

Samples & requirements

For cancer testing, we require two samples : one somatic sample from the tumour as fresh frozen tissue and a germline blood sample in an EDTA tube.

Where clinically appropriate (such as haem-onc cancers) and if no fresh or stored blood or fibroblast derived DNA is available, DNA extracted from saliva samples may be used.

Need to talk to someone?

We have a lot of information on our website, but if you need to talk to someone we are here for you.

Gst-tr.wgs@nhs.net for clinicians only to submit referrals and answer queries about ongoing referrals.

Gst-tr.hellogenomics@nhs.net if you have a clinical question or need help to submit a referral. This is also the email to use if you need training for your team about WGS such as consent training. This email can be used for patients who have whole genome sequencing queries.

Gst-tr.southeastglh@nhs.net for all other non-clinical questions relating to our laboratories, testing or funding questions.

Go to Test Ordering in Primary Care :
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