Clinical Indication ID & Name
Aminoglycoside exposure posing risk to hearing
Test Group
Core
Specialties
Test code
R65.1
Test name
N/A
Target genes
MT-RNR1 1555A>G
Test scope
n/a
Test method/ technology
Targeted mutation testing
Optimal Family Structure
n/a
Eligibility Criteria
Significant exposure to aminoglycosides posing risk of ototoxicity
This indication would be relevant to:
1. individuals with a predisposition to gram negative infections for example due to known respiratory disease (e.g. bronchiectasis, cystic fibrosis) or due to structural or voiding genitourinary tract disorders,
OR
2. individuals with hearing loss who have been exposed to aminoglycosides
Commissioning group
Core
Overlapping idications
• R67 Monogenic hearing loss should be used in individuals with unexplained hearing loss
Address for samples/request forms
Genetics Laboratory
5th Floor Tower Wing
Guy’s Hospital
London
SE1 9RT
Contact with queries
Supporting documents
n/a
Education resources
n/a
Turn around times
All our turnaround times are listed on our specific turn around page https://southeastgenomics.nhs.uk/professionals/service-turn-around-times/
Request form download
Consent record
See consent guidance in test request form
Sample requirements
Samples may be rejected for the following reasons: 1.Samples and request form do not show at least three identical patient identifiers 2.The sample is in the incorrect collection media 3.The request form is not sufficiently completed 4.The sample is not of sufficient volume 5.The sample is too old