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Order or find a test

The National Genomic Test Directories specify which genomic tests are commissioned by the NHS in England, to be delivered by Genomic Laboratory Hubs.

Clinical Indication ID & Name

R430

Inherited prostate cancer

Test Group

Core

Specialties

Clinical Genetics Oncology Urology

Test code

R430.1

Test name

N/A

Target genes

Inherited prostate cancer (1223)

Test scope

n/a

Test method/ technology

Inherited prostate cancer (1223)

Optimal Family Structure

n/a

Eligibility Criteria

•Proband diagnosed with prostate cancer at <50 years •Ashkenazi Jewish ancestry and prostate cancer at any age •≥1 grandparent from Whalsay (Shetland) and prostate cancer at any age •Proband diagnosed with metastatic prostate cancer <60 years •Proband diagnosed with prostate cancer with a CanRisk score of >10% and where they do not meet criteria for R208, R207 or R210 – see overlapping Clinical Indications
Deceased affected individual (proband) where all the following are met;
(i) the individual +/- family history meets one of the above criteria, AND
(ii) a previously stored constitutional blood/DNA or tissue sample (tumour or normal) is available, AND
(iii) no living affected individual is available for genetic testing, AND
(iv) after discussion at specialist cancer genetics MDT
Genetic testing may occasionally be appropriate outside these criteria following discussion at a specialist MDT with a cancer geneticist present.

Commissioning group

Core

Overlapping idications

R208 Inherited breast cancer and ovarian cancer - Proband affected with prostate cancer who has a personal/family history of other BRCA related cancers see R208 (BRCA related cancers = breast, ovarian, pancreatic, prostate). • R207 Inherited ovarian cancer (without breast cancer) • R210 Inherited MMR deficiency (Lynch syndrome) - For prostate cancer with personal/family history of other Lynch related cancers see R210 (See list of Lynch related cancers in R210). • R444 NICE approved PARP inhibitor treatment • M218 prostate cancer should be used for somatic testing Referrals for testing will be triaged by the Genomic Laboratory; testing should be targeted at those where a genetic or genomic diagnosis will guide management for the proband or family.

Address for samples/request forms

Genetics Laboratory
5th Floor Tower Wing
Guy’s Hospital
London
SE1 9RT

Contact with queries

gst-tr.southeastglh@nhs.net

Supporting documents

n/a

Education resources

n/a

Turn around times

All our turnaround times are listed on our specific turn around page https://southeastgenomics.nhs.uk/professionals/service-turn-around-times/

Request form download

Rare Disease Order Form Record of Discussion Form

Consent record

See consent guidance in test request form

Sample requirements

Sample Requirements Each sample must be sent labelled with 3 patient identifiers and must state the sample type clearly on the sample container. Sample Rejection Samples may be rejected for the following reasons: 1. Samples and request form do not show at least three identical patient identifiers 2. The sample is in the incorrect collection media 3. The request form is not sufficiently completed 4. The sample is not of sufficient volume 5. The sample is too old