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The National Genomic Test Directories specify which genomic tests are commissioned by the NHS in England, to be delivered by Genomic Laboratory Hubs.

Clinical Indication ID & Name

M92

Plasma Cell Dyscrasia

Test Group

Haematology

Specialties

Test code

M92.1

Test name

Multi-target NGS panel - small variant (KRAS, NRAS, BRAF, TP53, DIS3, TENT5C, IRF4)

Target genes

KRAS, NRAS, BRAF, TP53, DIS3, TENT5C, IRF4

Test scope

Small variant detection

Test method/ technology

Panel

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.2

Test name

t(4;14) IGH-FGFR3FISH/RT-PCR

Target genes

IGH-FGFR3

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.3

Test name

t(6;14) IGH-CCND3 FISH/RT-PCR

Target genes

IGH-CCND3

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.4

Test name

t(11;14)(q13;q32) IGH-CCND1 FISH/RT-PCR

Target genes

IGH-CCND1

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.5

Test name

t(14;16) IGH-MAF FISH/RT-PCR

Target genes

IGH-MAF

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.6

Test name

t(14;20) IGH-MAFB FISH/RT-PCR

Target genes

IGH-MAFB

Test scope

Structural variant detection

Test method/ technology

FISH/Simple targeted mutation testing

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.7

Test name

Multi-target NGS panel - structural variant (To include IGH-FGFR3, IGH-CCND3, IGH-CCND1, IGH-MAF, IGH-MAFB, MYC rearrangements)

Target genes

To include IGH-FGFR3, IGH-CCND3, IGH-CCND1, IGH-MAF, IGH-MAFB, MYC rearrangements

Test scope

Structural variant detection

Test method/ technology

Panel

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.8

Test name

IGH rearrangement FISH

Target genes

IGH

Test scope

Structural variant detection

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.9

Test name

Hyperdiploidy copy number FISH

Target genes

Hyperdiploidy

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.10

Test name

del(1p) copy number FISH

Target genes

del(1p) - CDKN2C

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.11

Test name

gain(1q) copy number FISH

Target genes

gain(1q) - CKS1B

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.12

Test name

del(17p) TP53 copy number FISH

Target genes

TP53

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.13

Test name

Multi-target NGS panel (To include hyperdiploidy, del(1p), gain(1q), del17p)

Target genes

Multiple chromosomes, Chr1p, Ch1q, Cr17p

Test scope

Copy number variant detection to genomewide resolution

Test method/ technology

Panel

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Test code

M92.14

Test name

MYC rearrangement FISH

Target genes

MYC

Test scope

Structural variant detection

Test method/ technology

FISH

Optimal Family Structure

n/a

Eligibility Criteria

Molecular assessment will aid diagnosis or management

Commissioning group

n/a

Overlapping idications

n/a

Address for samples/request forms

South East HMDS
c/o Central Specimen Reception
Synnovis Analytics
Ground Floor Bessemer Wing
King’s College Hospital
Denmark Hill, London SE5 9RS

Contact with queries

kch-tr.sehmdsreception@nhs.net

Supporting documents

n/a

Education resources

n/a

Turn around times

All our turnaround times are listed on our specific turn around page https://southeastgenomics.nhs.uk/professionals/service-turn-around-times/

Request form download

Cancer Haematology Order Form Haematology Sample Log Form Record of Discussion Form

Consent record

See consent guidance in test request form

Sample requirements

Samples may be rejected for the following reasons: 1.Samples and request form do not show at least three identical patient identifiers 2.The sample is in the incorrect collection media 3.The request form is not sufficiently completed 4.The sample is not of sufficient volume 5.The sample is too old