›
›

Order or find a test

The National Genomic Test Directories specify which genomic tests are commissioned by the NHS in England, to be delivered by Genomic Laboratory Hubs.

Clinical Indication ID & Name

R318

Recurrent miscarriage with products of conception available for testing

Test Group

Core

Specialties

Clinical Genetics Fetal Medicine Gynaecology Obstetrics

Test code

R318.1

Test name

Recurrent miscarriage with products of conception available for testing

Target genes

Genomewide

Test scope

n/a

Test method/ technology

Common aneuploidy testing

Optimal Family Structure

n/a

Eligibility Criteria

Recurrent miscarriage with products of conception available for testing – defined as three or more consecutive miscarriages.

Test code

R318.2

Test name

N/A

Target genes

Genomewide

Test scope

n/a

Test method/ technology

Microarray

Optimal Family Structure

n/a

Eligibility Criteria

Recurrent miscarriage with products of conception available for testing – defined as three or more consecutive miscarriages.

Commissioning group

Core

Overlapping idications

• R297 Possible structural chromosomal rearrangement - karyotype test should be used in parents of recurrent miscarriage where products of conception are not available for testing • R22 Fetus with a likely chromosomal abnormality after a second trimester loss where there are fetal anomalies and all third trimester fetal losses (IUD or stillbirth) or R21 Fetal anomalies with a likely genetic cause should be used in cases of second or third trimester intrauterine death or stillbirth • R318 Recurrent miscarriage (three or more consecutive miscarriages) with products of conception available for testing can be used where there has been recurrent miscarriage in the absence of additional features suggestive of chromosomal abnormality

Address for samples/request forms

Genetics Laboratory
5th Floor Tower Wing
Guy’s Hospital
London
SE1 9RT

Contact with queries

gst-tr.southeastglh@nhs.net

Supporting documents

n/a

Education resources

n/a

Turn around times

All our turnaround times are listed on our specific turn around page https://southeastgenomics.nhs.uk/professionals/service-turn-around-times/

Request form download

Rare Disease Order Form Record of Discussion Form

Consent record

See consent guidance in test request form

Sample requirements

Sample Requirements Each sample must be sent labelled with 3 patient identifiers and must state the sample type clearly on the sample container. Sample Rejection Samples may be rejected for the following reasons: 1. Samples and request form do not show at least three identical patient identifiers 2. The sample is in the incorrect collection media 3. The request form is not sufficiently completed 4. The sample is not of sufficient volume 5. The sample is too old Sample Storage and Volume Required: Placenta, fetal tissue sample, umbilical cord, as available, in a dry sterile container. Storage, sample packing and transportation: Dry, sterile, air-tight container without fixatives or preservatives. Skin biopsies or small samples of other solid tissue should be placed in a standard tissue culture medium. Patient/Clinician Instructions: Patient information and consent: Please ensure patient consent is obtained prior to the sample being sent to the laboratory for SNP microarray (please note patient consent forms should be stored and should NOT be sent to the laboratory). Referral information required: Referral form with detailed clinical information to support R318 or R22 Factors affecting performance of test/interpretation of results: DO NOT FIX IN FORMALIN.