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Webinar: Implementation of a Comprehensive NGS Oncology Panel including MSI and TMB Signatures

November 7 2018 @ 6:00 PM - 7:00 PM

This webinar will provide a first-hand look at how a leading pathology lab implemented a next-generation sequencing panel to capture comprehensive molecular tumor profiles.

As cancer genetics evolves and new clinical trials and data emerge, it has become increasingly critical to detect single nucleotide variants, insertions and deletions, as well as measuring copy number variations, microsatellite instability, and tumor mutational burden.

NGS serves as an important tool for such interrogations, but major gaps remain in performance robustness and interpretation algorithms. The implementation of a single assay, combined with an integrated bioinformatics pipeline, that assesses SNVs, indels, CNVs, MSI, and TMB enables efficiencies in sample usage, time, and cost.

Speaker, Dr. Ravindra Kolhe of Augusta University, will discuss his experience using the new QIAseq Tumor Mutational Burden panel coupled with QIAGEN’s bioinformatic solutions in comparison with a centralized testing model, focusing on:

  • QIAseq TMB panel content
  • Bioinformatics pipeline
  • Ease of adoption/integration
With any Whole Genome Sequencing (WGS) test ordered, a Record of Discussion (RoD) form will also need to be submitted. This document is to record the patient’s consent for genomic testing and their choice on taking part in research. Guidance on the patient choice conversation can be found here
This RoD form will be available for clinicians to download from this webpage. Once completed with the patient, it can be send to the lab with the corresponding test order form and sample.
Tests available to order will be listed in the National Genomic Test Directory. A test order form will soon be made available for clinicians on this webpage to download and complete. This form will include the address of the laboratory that the appropriate sample and completed form needs to be sent to.
Until the new Genomic Laboratory Service goes live, please continue to follow existing test order processes.
Later this year, the online test ordering tool for Whole Genome Sequencing will be integrated into the National Genomics Informatics System (NGIS) and clinicians will be able to search or filter to find a clinical indication, confirm eligibility criteria and start the test request process for their patient.