South East GLH

The NHS South East Genomic Laboratory Hub (GLH)

NHS England have reconfigured genetic laboratory services and commissioned 7 national Genomic Laboratory Hubs (GLH). The national GLH network will improve patient access for genetic testing and support the development of more personalised healthcare. The ultimate ambition is for patients with rare inherited diseases and cancer to be diagnosed and treated quicker than ever before, wherever they live.

The service allows clinicians to access testing for over 500 conditions, with some results being available in as little as three days. It will also enable the identification of gene mutations in cancer cells which can be targeted by new drug therapies.

National network of GMS regions (with key)
Map of GLH regions

The South East Genomic Laboratory Hub (SE GLH), a network of leading foundation trusts and pathology providers, has been commissioned to deliver genomic testing services across South London, Kent, Surrey and Sussex. The SE GLH provides genetic and genomic testing for a total of 20 acute NHS Trusts and 9 non-acute NHS Trusts, ensuring equitable access to testing for a population of 8.4 million.

 The SE GLH has also been commissioned to deliver specialist testing in 6 categories: cardiology, respiratory, gastro-hepatology, haematology, neurology and skin.

South East Consortium NHS Trusts​

External Partners

Whole Genome Sequencing

Genomic medicine is now part of mainstream NHS care and all healthcare professionals (not just genetics specialists) need to have a good understanding of its relevance. The pathway below outlines the Whole Genome Sequencing (WGS) pathway. 

Clinician requests a test from the National Test Directory by completing a Test Order Form and sending this to the GLH with the Patient Choice form and appropriate samples.
The GLH receive the forms and samples. The information from these forms are entered into the NGIS Test Ordering System. DNA is extracted from the samples.
The GLH sends the extracted DNA to be plated and sequenced. The genome data is quality checked and identified variants prioritised before the data is returned to the GLH.
The GLH performs interpretation and issues a NHS Genomic Report to the ordering clinician.
Resource library- Professionals

Library of resources

Carefully created and curated for healthcare professionals across the region to make the best use of genomics in their practice.

Calendar- Professionals

Education & events calendar

Our programme of genomics education for healthcare professionals is delivered through a mixture of face-to-face and online events.

HEE Genomics Education Programme

In-depth summaries, guides and training resources created by Health Education England
find out more
With any Whole Genome Sequencing (WGS) test ordered, a Record of Discussion (RoD) form will also need to be submitted. This document is to record the patient’s consent for genomic testing and their choice on taking part in research. Guidance on the patient choice conversation can be found here
This RoD form will be available for clinicians to download from this webpage. Once completed with the patient, it can be send to the lab with the corresponding test order form and sample.
Tests available to order will be listed in the National Genomic Test Directory. A test order form will soon be made available for clinicians on this webpage to download and complete. This form will include the address of the laboratory that the appropriate sample and completed form needs to be sent to.
Until the new Genomic Laboratory Service goes live, please continue to follow existing test order processes.
Later this year, the online test ordering tool for Whole Genome Sequencing will be integrated into the National Genomics Informatics System (NGIS) and clinicians will be able to search or filter to find a clinical indication, confirm eligibility criteria and start the test request process for their patient.