Testing of affected individual (proband) where the individual +/- family history meets one of the following criteria. The proband has:
1. Pancreatic cancer age <60, OR 2. Pancreatic cancer age <70, AND a. Breast cancer age <60, melanoma age <60, OR ovarian cancer, OR b. One first / second degree relative with pancreatic cancer age <60, OR c. Two or more first / second degree relatives with any of breast cancer age <60, melanoma age <60, OR ovarian cancer OR two or more with pancreatic cancer (any age) Deceased affected individual (proband) where all the following are met; (i) the individual +/- family history meets one of the above criteria, AND (ii) a previously stored constitutional blood/DNA or tissue sample (tumour or normal) is available, AND (iii) no living affected individual is available for genetic testing, AND (iv) after discussion at specialist cancer genetics MDT NOTE: The proband's cancer and majority of reported cancers in the family should have been confirmed. Pancreatic cancer is adenocarcinoma and not neuroendocrine tumour. If there is a family history of BRCA related cancers (breast, ovarian, prostate and pancreatic), please consider if R208 Inherited Breast Cancer panel testing is required. If there is a family history of melanoma, please consider if R254 Familial Melanoma panel testing is required. Genetic testing may occasionally be appropriate outside these criteria following discussion at a specialist MDT with a cancer geneticist present Referrals for testing will be triaged by the Genomic Laboratory; testing should be targeted at those where a genetic or genomic diagnosis will guide management for the proband or family.

Testing of affected individual (proband) where the individual +/- family history meets one of the following criteria. The proband has:
1. Pancreatic cancer age <60, OR 2. Pancreatic cancer age <70, AND a. Breast cancer age <60, melanoma age <60, OR ovarian cancer, OR b. One first / second degree relative with pancreatic cancer age <60, OR c. Two or more first / second degree relatives with any of breast cancer age <60, melanoma age <60, OR ovarian cancer OR two or more with pancreatic cancer (any age) Deceased affected individual (proband) where all the following are met; (i) the individual +/- family history meets one of the above criteria, AND (ii) a previously stored constitutional blood/DNA or tissue sample (tumour or normal) is available, AND (iii) no living affected individual is available for genetic testing, AND (iv) after discussion at specialist cancer genetics MDT NOTE: The proband's cancer and majority of reported cancers in the family should have been confirmed. Pancreatic cancer is adenocarcinoma and not neuroendocrine tumour. If there is a family history of BRCA related cancers (breast, ovarian, prostate and pancreatic), please consider if R208 Inherited Breast Cancer panel testing is required. If there is a family history of melanoma, please consider if R254 Familial Melanoma panel testing is required. Genetic testing may occasionally be appropriate outside these criteria following discussion at a specialist MDT with a cancer geneticist present Referrals for testing will be triaged by the Genomic Laboratory; testing should be targeted at those where a genetic or genomic diagnosis will guide management for the proband or family.