Testing of affected individual (proband) where the individual +/- family history meets one of the following criteria. The proband has:
1. Pancreatic cancer age <60, OR 2. Pancreatic cancer age <70, AND a. Breast cancer age <60, melanoma age <60, OR ovarian cancer, OR b. One first / second degree relative with pancreatic cancer age <60, OR c. Two first / second degree relatives with any of breast cancer age <60, melanoma age <60, OR ovarian cancer OR 3. Deceased affected individual (proband) where (i) the individual +/- family history meets one of the above criteria, (ii) appropriate tissue is available (tumour or normal), and (iii) no living affected individual is available for genetic testing NOTE: The proband's cancer and majority of reported cancers in the family should have been confirmed. Pancreatic cancer is adenocarcinoma and not neuroendocrine tumour. If there is a family history of BRCA related cancers (breast, ovarian, prostate and pancreatic), please consider if R208 Inherited Breast Cancer panel testing is required. If there is a family history of melanoma, please consider if R254 Familial Melanoma panel testing is required. Genetic testing may occasionally be appropriate outside these criteria following discussion at a specialist MDT with a cancer geneticist present

Testing of affected individual (proband) where the individual +/- family history meets one of the following criteria. The proband has:
1. Pancreatic cancer age <60, OR 2. Pancreatic cancer age <70, AND a. Breast cancer age <60, melanoma age <60, OR ovarian cancer, OR b. One first / second degree relative with pancreatic cancer age <60, OR c. Two first / second degree relatives with any of breast cancer age <60, melanoma age <60, OR ovarian cancer OR 3. Deceased affected individual (proband) where (i) the individual +/- family history meets one of the above criteria, (ii) appropriate tissue is available (tumour or normal), and (iii) no living affected individual is available for genetic testing NOTE: The proband's cancer and majority of reported cancers in the family should have been confirmed. Pancreatic cancer is adenocarcinoma and not neuroendocrine tumour. If there is a family history of BRCA related cancers (breast, ovarian, prostate and pancreatic), please consider if R208 Inherited Breast Cancer panel testing is required. If there is a family history of melanoma, please consider if R254 Familial Melanoma panel testing is required. Genetic testing may occasionally be appropriate outside these criteria following discussion at a specialist MDT with a cancer geneticist present