Testing of individual (proband) affected with renal cancer where the individual +/- family history meets one of the following criteria. The proband has
1. Renal cancer (≤ 46 years), OR
2. Type 2 papillary HLRCC associated RCC (WHO pathology definition) OR tubulo-papillary renal tumour at any age , OR
3. Bilateral/multifocal renal cancer (any age), OR
4. A renal cancer AND first degree relative with renal cancer, both cases diagnosed under 60 years of age
5. renal cancer AND second degree relative with renal cancer, both cases diagnosed under 50 years of age
6. Renal cancer and features of inherited cancer syndrome such as:
o Cerebellar/spinal haemangioblastoma
o Retinal angioma
o Phaeochromocytoma/paraganglioma
o Spontaneous pneumothorax
o Fibrofolliculomas
o Trichodiscomas
o Cutaneous Leiomyomata
o Uterine leiomyomas (under 40 years of age with pathology suggesting FH variant)
o Mesothelioma
o Uveal melanoma
Deceased affected individual (proband) where all the following are met;
(i) the individual +/- family history meets one of the above criteria, AND
(ii) a previously stored constitutional blood/DNA or tissue sample (tumour or normal) is available, AND
(iii) no living affected individual is available for genetic testing, AND
(iv) after discussion at specialist cancer genetics MDT
Referral to Clinical Genetics is required for karyotype in families with ≥3 FDR/SDR with renal cancer following MDT discussion
NOTE: The proband’s cancer and majority of reported cancers in the family should have been confirmed
Genetic testing may occasionally be appropriate outside these criteria following discussion at a specialist MDT with a cancer geneticist present
Referrals for testing will be triaged by the Genomic Laboratory; testing should be targeted at those where a genetic or genomic diagnosis will guide management for the proband or family.

Testing of individual (proband) affected with renal cancer where the individual +/- family history meets one of the following criteria. The proband has
1. Renal cancer (≤ 46 years), OR
2. Type 2 papillary HLRCC associated RCC (WHO pathology definition) OR tubulo-papillary renal tumour at any age , OR
3. Bilateral/multifocal renal cancer (any age), OR
4. A renal cancer AND first degree relative with renal cancer, both cases diagnosed under 60 years of age
5. renal cancer AND second degree relative with renal cancer, both cases diagnosed under 50 years of age
6. Renal cancer and features of inherited cancer syndrome such as:
o Cerebellar/spinal haemangioblastoma
o Retinal angioma
o Phaeochromocytoma/paraganglioma
o Spontaneous pneumothorax
o Fibrofolliculomas
o Trichodiscomas
o Cutaneous Leiomyomata
o Uterine leiomyomas (under 40 years of age with pathology suggesting FH variant)
o Mesothelioma
o Uveal melanoma
Deceased affected individual (proband) where all the following are met;
(i) the individual +/- family history meets one of the above criteria, AND
(ii) a previously stored constitutional blood/DNA or tissue sample (tumour or normal) is available, AND
(iii) no living affected individual is available for genetic testing, AND
(iv) after discussion at specialist cancer genetics MDT
Referral to Clinical Genetics is required for karyotype in families with ≥3 FDR/SDR with renal cancer following MDT discussion
NOTE: The proband’s cancer and majority of reported cancers in the family should have been confirmed
Genetic testing may occasionally be appropriate outside these criteria following discussion at a specialist MDT with a cancer geneticist present
Referrals for testing will be triaged by the Genomic Laboratory; testing should be targeted at those where a genetic or genomic diagnosis will guide management for the proband or family.