Clinical Indication ID & Name
Ovarian Carcinoma
Test Group
Solid Tumours (Adult)
Specialties
Test code
M2.1
Test name
Multi-target NGS panel - small variant (BRCA1, BRCA2, SMARCA4)
Target genes
BRCA1, BRCA2, SMARCA4
Test scope
Small variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Known high grade serous ovarian carcinoma or In cases of diagnostic uncertainty of small cell carcinoma of the ovary
Test code
M2.3
Test name
Multi-target NGS panel - structural variant (NTRK1, NTRK2, NTRK3)
Target genes
NTRK1, NTRK2, NTRK3
Test scope
Structural variant detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Patient’s clinical status means they are eligible for an NTRK inhibitor in the event an NTRK rearrangement is detected
Test code
M2.5
Test name
HRD status (either positive for BRCA 1 and/or 2, or HRD positive)
Target genes
BRCA1/2 and/or genomic instability
Test scope
Mutational signature detection
Test method/ technology
Panel
Optimal Family Structure
n/a
Eligibility Criteria
Patient is eligible for first line treatment and has a diagnosis of high grade ovarian cancer
Commissioning group
n/a
Overlapping idications
n/a
Address for samples/request forms
Cancer Genetics
Genetics Laboratories
5th Floor Tower Wing
Guy’s Hospital
Great Maze Pond
London
SE1 9RT
Contact with queries
Supporting documents
n/a
Education resources
n/a
Turn around times
All our turnaround times are listed on our specific turn around page https://southeastgenomics.nhs.uk/professionals/service-turn-around-times/
Request form download
Consent record
See consent guidance in test request form
Sample requirements
Samples may be rejected for the following reasons: 1.Samples and request form do not show at least three identical patient identifiers 2.The sample is in the incorrect collection media 3.The request form is not sufficiently completed 4.The sample is not of sufficient volume 5.The sample is too old