Clinical Indication ID & Name
Subcutaneous panniculitis T-cell lymphoma (SPTCL)
Test Group
Dermatology
Specialties
Test code
R424.1
Test name
N/A
Target genes
HAVCR2
Test scope
n/a
Test method/ technology
Single gene sequencing >=10 amplicons
Optimal Family Structure
n/a
Eligibility Criteria
1. New diagnosis of SPTCL (to guide therapeutic management)
2. Suspected SPTCL (to aid diagnosis)
Detection of the germline HAVCR2 variant is associated with the life-threatening complication of haemophagocytic lymphohistiocytosis (HLH) in a subset of SPTCL patients and also indicates which patients may benefit from immunosuppressive therapy (eg Cyclosporin) as opposed to chemotherapy
Test code
R424.2
Test name
N/A
Target genes
Test scope
n/a
Test method/ technology
n/a
Optimal Family Structure
n/a
Eligibility Criteria
1. New diagnosis of SPTCL (to guide therapeutic management)
2. Suspected SPTCL (to aid diagnosis)
Detection of the germline HAVCR2 variant is associated with the life-threatening complication of haemophagocytic lymphohistiocytosis (HLH) in a subset of SPTCL patients and also indicates which patients may benefit from immunosuppressive therapy (eg Cyclosporin) as opposed to chemotherapy
Commissioning group
Specialised
Overlapping idications
n/a
Address for samples/request forms
Genetics Laboratory
5th Floor Tower Wing
Guy’s Hospital
London
SE1 9RT
Contact with queries
Supporting documents
n/a
Education resources
n/a
Turn around times
All our turnaround times are listed on our specific turn around page https://southeastgenomics.nhs.uk/professionals/service-turn-around-times/
Request form download
Consent record
See consent guidance in test request form
Sample requirements
Samples may be rejected for the following reasons: 1.Samples and request form do not show at least three identical patient identifiers 2.The sample is in the incorrect collection media 3.The request form is not sufficiently completed 4.The sample is not of sufficient volume 5.The sample is too old