Clinical Indication ID & Name
Y chromosome microdeletion
Test Group
Core
Specialties
Test code
R411.1
Test name
N/A
Target genes
Y chromosome AZF regions
Test scope
n/a
Test method/ technology
Targeted mutation testing or equivalent
Optimal Family Structure
n/a
Eligibility Criteria
Patients with non-obstructive azoospermia or severe oligospermia where testicular sperm extraction (TESE)/microdissection TESE (mTESE) is considered and outcome of testing will inform eligibility for (m)TESE and success of sperm retrieval (https://www.england.nhs.uk/wp-content/uploads/2018/07/Surgicalsperm-retrieval-for-male-infertility.pdf)
Testing for Y chromosome microdeletions should not routinely be performed before ICSI
(https://www.nice.org.uk/guidance/cg156/chapter/Recommendations)
Testing for this clinical indication is performed by designated GLHs on behalf of the national genomic testing network
Commissioning group
Core
Overlapping idications
• R298 - Possible structural or mosaic chromosomal abnormality requiring FISH
Address for samples/request forms
Genetics Laboratory
5th Floor Tower Wing
Guy’s Hospital
London
SE1 9RT
Contact with queries
Supporting documents
n/a
Education resources
n/a
Turn around times
All our turnaround times are listed on our specific turn around page https://southeastgenomics.nhs.uk/professionals/service-turn-around-times/
Request form download
Consent record
See consent guidance in test request form
Sample requirements
Samples may be rejected for the following reasons: 1.Samples and request form do not show at least three identical patient identifiers 2.The sample is in the incorrect collection media 3.The request form is not sufficiently completed 4.The sample is not of sufficient volume 5.The sample is too old