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Order or find a test

The National Genomic Test Directories specify which genomic tests are commissioned by the NHS in England, to be delivered by Genomic Laboratory Hubs.

Clinical Indication ID & Name

R459

Young onset or complex Parkinson disease

Test Group

Neurology

Specialties

Clinical Genetics Neurology Psychiatry

Test code

R459.1

Test name

Young onset or complex Parkinson disease

Target genes

Test scope

Exon level CNVs, Small variants, STRs

Test method/ technology

WGS

Optimal Family Structure

n/a

Eligibility Criteria

Testing Criteria
Parkinson’s disease or complex Parkinsonism with a likely monogenic cause AND
a. Age at onset <50 years, OR b. First degree relative affected at <50 years, OR c. Complex features such as spasticity, gaze palsy, early dementia, early bulbar failure, dyspraxia, ataxia, postural hypotension, cortical sensory loss, iron accumulation on brain MRI. Where in Pathway At presentation following assessment by a Neurologist

Commissioning group

n/a

Overlapping idications

The gene content of the Adult onset neurological disorders panel includes all genes on Hereditary ataxia with onset in adulthood (R54), Adult onset dystonia, chorea or related movement disorder (R56) Adult onset neurodegenerative disorders (previously R58, now R458, R459, R460 & R461), Adult onset hereditary spastic paraplegia (R60)

Address for samples/request forms

Contact with queries

Supporting documents

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Education resources

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Turn around times

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Request form download

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Consent record

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Sample requirements

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