Order or find a test

The National Genomic Test Directories specify which genomic tests are commissioned by the NHS in England, to be delivered by Genomic Laboratory Hubs.

Clinical Indication ID & Name

R207

Inherited ovarian cancer (without breast cancer)

Test Group

Core

Specialties

Oncology Clinical Genetics Gynaecology

Test code

R207.1

Test name

N/A

Target genes

Inherited ovarian cancer (without breast cancer) (143)

Test scope

n/a

Test method/ technology

Small panel

Optimal Family Structure

n/a

Eligibility Criteria

1. High grade non mucinous epithelial ovarian cancer (EOC) at any age
OR
2. Epithelial ovarian cancer (EOC) AND
a. ≥1 first degree relative with EOC, OR
b. ≥1 second degree relative with EOC (intervening relative is male, OR female with BSO, OR female deceased) OR
c. ≥2 second / third degree relatives with EOC
3. Deceased affected individual (proband) where criteria 2 are reached (or family Manchester score of 20) and:
a. Appropriate tissue is available (tumour or normal) AND
b. No living affected individual is available for genetic testing

NOTE: The proband’s cancer and majority of reported cancers in the family should have been confirmed

Test code

R207.2

Test name

N/A

Target genes

Inherited ovarian cancer (without breast cancer) (143)

Test scope

n/a

Test method/ technology

MLPA or equivalent

Optimal Family Structure

n/a

Eligibility Criteria

1. High grade non mucinous epithelial ovarian cancer (EOC) at any age
OR
2. Epithelial ovarian cancer (EOC) AND
a. ≥1 first degree relative with EOC, OR
b. ≥1 second degree relative with EOC (intervening relative is male, OR female with BSO, OR female deceased) OR
c. ≥2 second / third degree relatives with EOC
3. Deceased affected individual (proband) where criteria 2 are reached (or family Manchester score of 20) and:
a. Appropriate tissue is available (tumour or normal) AND
b. No living affected individual is available for genetic testing

NOTE: The proband’s cancer and majority of reported cancers in the family should have been confirmed

Commissioning group

Core

Overlapping idications

• M2 Ovarian carcinoma should be used for somatic testing

Address for samples/request forms

Genetics Laboratory
5th Floor Tower Wing
Guy’s Hospital
London
SE1 9RT

Contact with queries

gst-tr.southeastglh@nhs.net

Supporting documents

n/a

Education resources

n/a

Turn around times

All our turnaround times are listed on our specific turn around page https://southeastgenomics.nhs.uk/professionals/service-turn-around-times/

Request form download

Rare Disease Order Form Record of Discussion Form

Consent record

See consent guidance in test request form

Sample requirements

Samples may be rejected for the following reasons: 1.Samples and request form do not show at least three identical patient identifiers 2.The sample is in the incorrect collection media 3.The request form is not sufficiently completed 4.The sample is not of sufficient volume 5.The sample is too old