Clinical Indication ID & Name
Possible structural or mosaic chromosomal abnormality - FISH
Test Group
Core
Specialties
Test code
R298.1
Test name
N/A
Target genes
As determined by indication
Test scope
n/a
Test method/ technology
FISH
Optimal Family Structure
n/a
Eligibility Criteria
Possible structural or mosaic chromosomal abnormality requiring FISH
Testing for Y chromosome microdeletions should not routinely be performed before ICSI
https://www.nice.org.uk/guidance/cg156/chapter/Recommendations
Commissioning group
Core
Overlapping idications
• R26 Likely common aneuploidy, test should be used for common aneuploidy testing, which may be delivered by FISH • R297 Possible structural chromosomal rearrangement – karyotype, is available where karyotype alone is required • R265 Chromosomal mosaicism – karyotype, is available where extended karyotype is required • R411 Y chromosome microdeletions is available where surgical sperm retrieval is considered
Address for samples/request forms
Genetics Laboratory
5th Floor Tower Wing
Guy’s Hospital
London
SE1 9RT
Contact with queries
Supporting documents
n/a
Education resources
n/a
Turn around times
All our turnaround times are listed on our specific turn around page https://southeastgenomics.nhs.uk/professionals/service-turn-around-times/
Request form download
Consent record
See consent guidance in test request form
Sample requirements
Samples may be rejected for the following reasons: 1.Samples and request form do not show at least three identical patient identifiers 2.The sample is in the incorrect collection media 3.The request form is not sufficiently completed 4.The sample is not of sufficient volume 5.The sample is too old