1. Sudden death in child less than 18 years that remains unexplained after the standard investigation protocols, Joint Agency Response (JAR) review of circumstances of death and post-mortem AND
2. Confirmation from requesting clinician that 1. is fulfilled AND
o DNA is available from proband and both biological parents for trio WGS analysis OR
o Where only one parent, or neither parents, are available for testing then testing the deceased infant/child may proceed in exceptional circumstances. A discussion is required between the clinical team involved and the testing laboratory to consider the most appropriate testing approach and how to proceed.

Test Exclusion; Testing should not be performed where the likelihood of a monogenic disorder is low, for example where the available evidence supports a non-genetic cause of death (e.g. severe infection, suspicious death/homicide investigation).
Where in Pathway
Statutory Child Death Review Process for all unexpected deaths includes Joint Agency Response (JAR) review of medical and family history, and circumstances of death.
After standard SIDS/SUDC protocol including JAR review and post-mortem have been completed. Following specialist MDT discussion of patients that may be suitable for WGS (including e.g. pathology, designated doctor for child deaths, clinical genetics as appropriate). Consent will need to be obtained from family.